DIDS sodium salt

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

DIDS 钠盐是 ABCA1 和 VDAC1 的双重抑制剂。

DIDS sodium salt is a dual inhibitor of ABCA1 and VDAC1.

Concentration less than 400 μM DIDS has no evident cytotoxic effect on cell viability Pre-treatment with DIDS at the concentration of 100 and 200 μM result in a prevented effect on ALA-SDT-induced cell death, while dose at 50 μM has no inhibition effect. At the concentration of 400 μM DIDS itself slightly decreases the cell viability, although there is no significant statistic difference as compared with the untreated control. Pre-treatment with DIDS (100 μM) clearly inhibit caspase-3 and caspase-9 activation.

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MDL101114ZA

Cell Cycle/DNA Damage

ABC

ABCA1|VDAC1

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67483-13-0

498.48

C16H8N2Na2O6S4

>98% (HPLC)

DMSO:50 mg/mL (100.30 mM; Need ultrasonic)

C1=CC(=C(C=C1N=C=S)S(=O)(=O)[O-])/C=C/C2=C(C=C(C=C2)N=C=S)S(=O)(=O)[O-].[Na+].[Na+]

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(-20℃)

With Ice Pack

≥ 2 years